Nitric Oxide Administration Using an Oxygen Hood: A Pilot Trial

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Nitric Oxide Administration Using an Oxygen Hood: A Pilot Trial

BACKGROUND We have shown earlier that inhaled nitric oxide (iNO) administered by oxygen hood reduces pulmonary hypertension in an animal model (J Perinatol 2002; 22:50-6). Our objective in this study was to determine feasibility of iNO by oxygen hood in neonates with elevated alveolar-arterial oxygen gradients (A-aDO(2)). METHODS/PRINCIPAL FINDINGS Masked randomized controlled pilot trial. In...

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Evaluation of adherence to oxygen therapy standards before, during and after oxygen hood administration

Background and Purpose: Oxygen therapy is one of the common treatments for neonates with cardiopulmonary disease. The aim of this study was to evaluate adherence to oxygen therapy standards by nurses before, during and after using oxygen hood. Methods: In this cross-sectional study, 250 cases of nursing care were evaluated before, during and after administration of oxygen hood therapy in pre...

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Nitric oxide administration using constant-flow ventilation.

Nitric oxide (NO) gas is known as both a vasodilator and a toxin. It can react with oxygen to form compounds more toxic than itself, such as nitrogen dioxide (NO2). The reactions are time dependent; thus, infusing NO into breathing circuits as close to ventilated subjects as possible may help minimize toxic byproduct exposure. Unfortunately, flow rates commonly used with mechanical ventilation ...

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Nitric oxide and oxygen metabolism.

Introduction Inhibition of mitochondrial respiration has been associated with the cytotoxicity of NO right from the beginning of NO research [1,2]. Recent findings have confirmed the importance of mitochondrial inhibition, but put the previous research into a new context. Here we review our findings that: (a) NO reversibly inhibits O2 consumption by isolated cytochrome oxidase, mitochondria, ne...

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evaluation of adherence to oxygen therapy standards before, during and after oxygen hood administration

background and purpose: oxygen therapy is one of the common treatments for neonates with cardiopulmonary disease. the aim of this study was to evaluate adherence to oxygen therapy standards by nurses before, during and after using oxygen hood. methods: in this cross-sectional study, 250 cases of nursing care were evaluated before, during and after administration of oxygen hood therapy in preter...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2009

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0004312